| Author: Shafiqul A. Sarker, Neha Pant, Lekh R. Juneja, Lennart Hammarström |
| InfoShare Partner: ICDDR,B |
| Publication Date: December 2007 |
| Type of Document: Article/Report/Paper |
| Topics: Child health/survival, Infectious diseases, other |
| Region: Asia/Pacific |
| Language: English |
| Additional information: Sectional PDF and HTML files available on the website |
| Number of Pages: 4 |
| File Size: 148 KB |
| File Format: Adobe Acrobat (PDF) To read PDF files, you must have Acrobat Reader installed. Visit Adobe's web site to get a free copy of Acrobat Reader. [download here]
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The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting.
Journal of Health, Population and Nutrition, 25(4):465-468
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